Rural Chinese women who listed late-onset menarche were 22% much less prone to develop sort two diabetes in maturity when compared with comparable women reporting menarche from age 16 to 17 years, in line with an analysis of more than 15,000 women published in Menopause.
Lulu Zhang, MD stated, most epidemiology studies on the connection between menarche age and type 2 diabetes have been conducted in Western countries, however only some research has been carried out in China, particularly in Chinese rural areas. “Our research has aimed to find out whether or not age at menarche in our research population varies from that of Western countries, to look at the connection between age at menarche and type 2 diabetes and to determine the balance that might be associated with adiposity (BMI).”
Zhang and colleagues investigated data from 15,346 postmenopausal women who underwent a blood glucose test and provided the age at menarche as part of the Henan Rural Cohort research, conducted from the following date, July 2015 to September 2017 mean age, 62 years; mean age at menarche, 16.1 years. Researchers scaled contributors by quintiles according to reported age at menarche aged 14 years; age 15 years; aged 16-17 years; old 18 years and aged 19 years and used logistic regression and limited cubic spline analyses to estimate the relationship between age at menarche and sort two diabetes. Mediation analysis was used to research whether BMI mediated the association.
After adjustment for age at recruitment, researchers found that every year of delay in menarche age associated with a 6% decrease threat for type 2 diabetes.
“It has been considered that early menarche may result in greater accumulation of adipose tissue,” the researchers wrote. “Increased adiposity triggers low-grade inflammation that’s thought to result in native insulin resistance and subsequently contribute to systemic insulin resistance and hyperinsulinemia, which, in turn, results in dysglycemia. Certainly, in our research, we found that BMI partially mediated the connection between age at menarche and type 2 diabetes.”