RESEARCH HAS DEVELOPED A UNIQUE 3D PRINTED SYSTEM FOR HARVESTING STEM CELLS FROM BIOREACTORS.

Researchers have created a one-of-a-kind 3D printed technology for extracting stem cells from bioreactors, potentially allowing for high-quality, large-scale stem cell production in Australia at a reduced cost.

Because of their potential to replace damaged time-consuming labor-intensive arable promise in the treatment of a variety of diseases and injuries, ranging from arthritis to diabetes to cancer. However, the existing technology for harvesting stem cells is time-consuming, labor-intensive, and costly.

Professor Warkiani stated, “Our cutting-edge technology, which integrates a variety of production procedures into one device using 3D printing and microfluidics, can help make stem cell therapies more broadly available to patients at a reduced cost.” The translational research was headed by biomedical engineer Professor Majid Warkiani of the University of Technology Sydney, in partnership with Regeneus, an Australian biotechnology company producing stem cell therapeutics to treat inflammatory disorders and pain.

We are collaborating closely with biotechnology businesses to commercialize this world-first system, which is now in the prototype stage. “Most importantly, it is a closed system that does not require human intervention, which is required for existing good manufacturing procedures,” he explained. Microfluidics is the exact management of fluid at microscopic scales, which allows cells and particles to be manipulated. Advances in 3D printing have made it possible to produce microfluidic equipment directly, allowing for quick prototyping and the creation of integrated systems.

The novel method was designed to handle mesenchymal stem cells, a type of adult stem cell that can proliferate and differentiate into a variety of tissue cells such as bone, cartilage, muscle, fat, and connective tissue. A modular 3D printed microfluidic system: a viable solution for continuous cell harvesting in large-scale bioprocessing was recently published in Bioresources and Bioprocessing.

Structures made from bio print are Not a plastic model it can work and function properly like other parts. Scientists are not able to build complex structures but they can print similar structures which comprise blood vessels and tubes responsive to nutrient transfers and waste exchange. Bioprinting is like a version of 3D printing which is used to construct 3D dimensions of a series of materials.

These 3D printers are so advanced that they can produce the structure within 30 minutes. These bio-inks are pushed into a round nozzle bound to a print head. The structure is produced through a nozzle which can generate fragments like the consistency of a human fingernail continuously. To stabilize, the structure scientist takes the help of a computerized image to tutor the placement of the structure either onto the surface or into the water which will help it to stabilize.

After printing a bio-ink, some of them get stiffed immediately but the others have to go through UV light or a physical procedure, etc to stabilize the structure. If this turned out to be successful then the cells in that structure start working as the real cells in the body and adapt to the body’s environment. The cells start signaling to each other like earlier and also exchange nutrients and multiply.

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